Regulation of fibrinolysis

Across TCGA cell cohorts, RNA activity of the Regulation of fibrinolysis pathway is significantly associated with the shRNA dependency of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VSX2, MAX, and PPP1R12A, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, VSX2 grouped by Regulation of fibrinolysis-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	VSX2 →	-0.490	-0.477	.009	<.001	2	7
BONE	MAX →	-0.580	-0.452	.001	<.001	3	6
PANCREAS	PPP1R12A →	+0.498	+0.333	<.001	<.001	3	6
SKIN	KDELR1 →	-0.169	-0.265	.007	.002	3	6
BLOOD_Lymphoma	TECR →	+0.315	+0.223	.005	.003	3	5
BLOOD_Leukemia	PPP3R2 →	+0.190	+0.218	.002	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

VSX2 by Regulation of fibrinolysis activity — BONE

Explore this box plot interactively →