Regulation of fibrinolysis

Across TCGA cell cohorts, RNA activity of the Regulation of fibrinolysis pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are XRCC6, ARHGEF28, and IRX4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, XRCC6 grouped by Regulation of fibrinolysis-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	XRCC6 →	+0.476	+0.443	.004	<.001	3	4
SKIN	ARHGEF28 →	-0.098	-1.230	<.001	<.001	3	3
BLOOD_Lymphoma	IRX4 →	-0.360	-0.363	.004	.007	3	3
SKIN	DCAF4 →	-0.142	-1.375	.005	<.001	3	3
SKIN	SLC9A5 →	-0.227	-1.244	.001	<.001	3	3
LUNG_SCLC	PDXK →	-0.132	-0.292	.007	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

XRCC6 by Regulation of fibrinolysis activity — BLOOD_Lymphoma

Explore this box plot interactively →