Positive regulation of mitochondrial depolarization

Across TCGA patient cohorts, RNA activity of the Positive regulation of mitochondrial depolarization pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MAP3K8_S141, CALD1_S759, and PHKA1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of mitochondrial depolarization activity versus MAP3K8_S141 in GBM (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MAP3K8_S141 →	+0.561	+0.102	.001	.001	3	5
UCEC	CALD1_S759 →	+0.853	+0.113	<.001	.002	3	4
OV	PHKA1 →	-0.450	-0.036	.002	.007	3	4
BRCA	RCN1 →	+0.473	+0.040	<.001	.001	3	4
LSCC	RIN3 →	+0.240	+0.042	<.001	<.001	3	4
LSCC	SAMD4A_S420 →	+0.545	+0.057	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051901 vs MAP3K8_S141 — GBM

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