Positive regulation of mitochondrial depolarization

Across TCGA patient cohorts, RNA activity of the Positive regulation of mitochondrial depolarization pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LMO2, IGFBP5, and EEF1A1P27, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of mitochondrial depolarization activity versus LMO2 in CCRCC (Pearson r = -0.00).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	LMO2 →	-0.469	-0.099	.004	.008	3	4
BRCA	IGFBP5 →	-1.075	-0.143	.005	<.001	3	3
GBM	EEF1A1P27 →	-0.218	-0.115	.005	<.001	3	3
CCRCC	DNAJB5 →	-0.558	-0.121	<.001	.002	3	3
CCRCC	RNU6-1091P →	+0.448	+0.090	.005	.005	3	3
CCRCC	RN7SL140P →	+0.137	+0.126	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051901 vs LMO2 — CCRCC

Explore this scatter interactively →