Positive regulation of mitochondrial depolarization

Across TCGA cell cohorts, RNA activity of the Positive regulation of mitochondrial depolarization pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UBXN2B, LMBR1, and VCP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, UBXN2B grouped by Positive regulation of mitochondrial depolarization-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	UBXN2B →	-0.610	-1.244	.004	<.001	3	5
CNS	LMBR1 →	-0.651	-1.116	.003	<.001	3	4
CNS	VCP →	-0.558	-1.087	.005	.001	3	4
BLOOD_Leukemia	RBP5 →	-1.468	-1.318	.004	<.001	3	4
LUNG_NSCLC_LUAD	SEC24C →	-0.582	-0.807	<.001	.001	3	4
LUNG_NSCLC_LUSC	SMOX →	-1.613	-1.091	.003	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

UBXN2B by Positive regulation of mitochondrial depolarization activity — OVARY

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