Membrane depolarization

Across TCGA patient cohorts, RNA activity of the Membrane depolarization pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EPB41L3, CNRIP1, and ANK2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Membrane depolarization activity versus EPB41L3 in OV (Pearson r = 0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	EPB41L3 →	+0.697	+0.019	<.001	.001	3	8
CCRCC	CNRIP1 →	+0.505	+0.042	<.001	<.001	3	8
UCEC	ANK2 →	+0.660	+0.054	<.001	<.001	3	8
UCEC	PURA →	+0.296	+0.043	.001	<.001	3	8
LSCC	SRPK1_S311 →	-0.465	-0.035	.001	.008	3	8
GBM	NUP93_S52 →	-0.377	-0.066	.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051899 vs EPB41L3 — OV

Explore this scatter interactively →