Membrane depolarization

Across TCGA patient cohorts, RNA activity of the Membrane depolarization pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLU, SCTR-AS1, and ARHGAP11A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Membrane depolarization activity versus CLU in HNSC (Pearson r = 0.19).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CLU →	+1.252	+0.864	.004	.003	3	5
LUAD	SCTR-AS1 →	+1.022	+0.598	<.001	<.001	3	5
LUAD	ARHGAP11A →	-0.577	-0.544	<.001	<.001	3	5
UCEC	MAPRE1 →	-0.342	-0.525	<.001	<.001	3	4
LUAD	E2F3 →	-0.426	-0.597	.002	.001	2	5
UCEC	CENPF →	-0.996	-0.704	.004	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051899 vs CLU — HNSC

Explore this scatter interactively →