Membrane depolarization

Across TCGA cell cohorts, RNA activity of the Membrane depolarization pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAP3K20, CP, and PPM1A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MAP3K20 grouped by Membrane depolarization-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	MAP3K20 →	+1.800	+1.186	.002	.005	3	4
OVARY	CP →	-3.225	-0.876	.003	.007	3	4
CNS	PPM1A →	-0.450	-0.557	<.001	.003	3	3
LIVER	NEURL2 →	-0.905	-1.167	<.001	<.001	3	3
CNS	GPATCH3 →	-0.504	-0.852	.001	.001	3	3
CNS	STXBP2 →	-1.837	-0.600	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MAP3K20 by Membrane depolarization activity — LUNG_SCLC

Explore this box plot interactively →