Membrane depolarization

Across TCGA cell cohorts, RNA activity of the Membrane depolarization pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAV2, USP11, and APBB1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Membrane depolarization activity versus CAV2 in BREAST (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CAV2 →	+3.384	+0.286	.004	<.001	3	6
BLOOD_Leukemia	USP11 →	+0.928	+0.197	.001	.001	3	5
LUNG_NSCLC_LUAD	APBB1 →	+1.734	+0.434	<.001	.005	3	5
LUNG_SCLC	CLMP →	+2.292	+0.357	<.001	<.001	2	6
LUNG_NSCLC_LUAD	TUBA1A →	+2.370	+0.497	.002	.008	3	5
LUNG_SCLC	GDI1 →	+0.952	+0.404	.006	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051899 vs CAV2 — BREAST

Explore this scatter interactively →