Negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

Across TCGA patient cohorts, RNA activity of the Negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPS8, CNRIP1, and SH3BGRL3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction activity versus RPS8 in CCRCC (Pearson r = -0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	RPS8 →	-0.227	-0.034	<.001	<.001	3	6
OV	CNRIP1 →	+0.494	+0.030	.006	.005	3	6
OV	SH3BGRL3 →	+0.296	+0.031	.003	.002	3	6
LUAD	TESPA1_S311 →	+0.553	+0.043	.002	.002	3	6
LSCC	TRIM21 →	+0.346	+0.055	<.001	<.001	3	6
UCEC	H2AX_Y143 →	-1.167	-0.050	.003	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051898 vs RPS8 — CCRCC

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