Negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

Across TCGA patient cohorts, RNA activity of the Negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MCM3, FANCI, and KIF15, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction activity versus MCM3 in LSCC (Pearson r = -0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MCM3 →	-0.732	-0.557	.001	<.001	3	5
LSCC	FANCI →	-0.805	-0.521	.001	.002	3	5
HNSC	KIF15 →	-0.816	-0.630	.002	.004	3	5
LSCC	CDC45 →	-0.630	-0.346	<.001	.009	3	5
LUAD	PRR11 →	-0.595	-0.252	.005	.002	3	5
HNSC	NCAPH →	-0.493	-0.500	.006	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051898 vs MCM3 — LSCC

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