Negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

Across TCGA cell cohorts, RNA activity of the Negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EXT2, HLA-A, and LIAS, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction activity versus EXT2 in LUNG_SCLC (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	EXT2 →	+0.672	+0.167	.002	.001	3	5
OVARY	HLA-A →	+2.217	+0.221	.006	.004	1	7
URINARY_TRACT	LIAS →	-1.298	-0.473	.005	.006	3	4
URINARY_TRACT	PPAT →	-0.702	-0.343	.002	.006	2	5
LUNG_NSCLC_LUSC	CENPI →	+0.986	+0.274	.001	.002	3	4
CNS	ADRM1 →	+0.667	+0.214	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051898 vs EXT2 — LUNG_SCLC

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