Positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

Across TCGA patient cohorts, RNA activity of the Positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SNX9, STAB1, and SYNPO_S833, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction activity versus SNX9 in OV (Pearson r = 0.52).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SNX9 →	+0.527	+0.060	<.001	<.001	3	10
LSCC	STAB1 →	+0.449	+0.067	<.001	<.001	3	10
BRCA	SYNPO_S833 →	+0.643	+0.035	.003	<.001	3	10
OV	TBC1D2B →	+0.395	+0.050	<.001	<.001	3	10
CCRCC	TNS2 →	+0.491	+0.043	<.001	<.001	3	10
BRCA	BGN →	+0.934	+0.041	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051897 vs SNX9 — OV

Explore this scatter interactively →