Positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

Across TCGA patient cohorts, RNA activity of the Positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C3orf86, LRRK2, and PRDM8, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction activity versus C3orf86 in UCEC (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C3orf86 →	+0.379	+0.158	.004	.005	3	5
COAD	LRRK2 →	+0.711	+0.116	<.001	.002	3	4
COAD	PRDM8 →	+0.728	+0.084	<.001	.002	3	4
COAD	C11orf96 →	+1.008	+0.160	<.001	<.001	3	4
COAD	GFPT2 →	+1.017	+0.109	<.001	<.001	3	4
COAD	HLX →	+0.254	+0.097	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051897 vs C3orf86 — UCEC

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