Positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

Across TCGA cell cohorts, RNA activity of the Positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IQGAP1, MFSD4B, and FAM71E1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IQGAP1 grouped by Positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	IQGAP1 →	-0.575	-1.295	.007	.001	3	4
BLOOD_Myeloma	MFSD4B →	+0.777	+0.235	.001	.008	3	4
LUNG_SCLC	FAM71E1 →	+1.488	+0.182	.001	<.001	3	3
LUNG_SCLC	EXD1 →	+0.298	+0.172	.005	.006	3	3
LUNG_SCLC	CEBPA →	+1.622	+0.139	<.001	.006	2	4
LUNG_SCLC	HACD3 →	+0.953	+0.158	.002	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IQGAP1 by Positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction activity — KIDNEY

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