Regulation of cardioblast differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of cardioblast differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ENAH, TGFB2, and MRC2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cardioblast differentiation activity versus ENAH in CCRCC (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ENAH →	+0.392	+0.080	<.001	<.001	3	7
UCEC	TGFB2 →	+0.918	+0.126	<.001	<.001	3	7
BRCA	MRC2 →	+0.558	+0.055	<.001	<.001	3	7
PDAC	P3H3 →	+0.538	+0.101	<.001	<.001	3	7
CCRCC	TAGLN →	+0.668	+0.057	.004	.006	3	6
CCRCC	ACTN1 →	+0.465	+0.089	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051890 vs ENAH — CCRCC

Explore this scatter interactively →