Regulation of cardioblast differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of cardioblast differentiation pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRICKLE1, MINAR1, and LCA5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cardioblast differentiation activity versus PRICKLE1 in HNSC (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PRICKLE1 →	+0.668	+0.561	<.001	.005	3	4
CCRCC	MINAR1 →	+0.408	+0.491	<.001	.001	3	4
BRCA	LCA5 →	+0.503	+0.359	.008	.003	3	4
UCEC	TMX4 →	+0.637	+0.402	.001	.002	3	4
PDAC	PDSS1 →	-0.258	-0.439	.004	.005	3	3
LSCC	ITFG1-AS1 →	+0.330	+0.250	.006	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051890 vs PRICKLE1 — HNSC

Explore this scatter interactively →