Regulation of cardioblast differentiation

Across TCGA cell cohorts, RNA activity of the Regulation of cardioblast differentiation pathway is significantly associated with the drug response of multiple features, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are Camptothecin, SB216763, and Afatinib, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, Camptothecin grouped by Regulation of cardioblast differentiation-low versus -high activity in CNS.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Camptothecin →	-0.625	-0.603	.045	.018	1	1
CNS	SB216763 →	-0.915	-0.603	.012	.018	1	1
CNS	Afatinib →	-0.319	-0.603	.036	.018	1	1
CNS	JNK Inhibitor VIII →	+0.679	+0.603	.001	.018	1	1
CNS	CCT245467 →	-1.004	-0.603	.009	.018	1	1
CNS	N24798-49-A1 →	-0.250	-0.603	.037	.018	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Camptothecin by Regulation of cardioblast differentiation activity — CNS

Explore this box plot interactively →