Mitochondrial depolarization

Across TCGA patient cohorts, RNA activity of the Mitochondrial depolarization pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ARHGAP25_S512, STK10, and GIMAP7, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial depolarization activity versus ARHGAP25_S512 in LSCC (Pearson r = -0.16).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ARHGAP25_S512 →	+0.762	+0.067	<.001	<.001	3	8
LSCC	STK10 →	+0.305	+0.048	<.001	<.001	3	8
HNSC	GIMAP7 →	+0.645	+0.078	<.001	<.001	3	8
LSCC	CORO1A →	+0.414	+0.046	<.001	<.001	3	7
GBM	FYB1 →	+0.608	+0.073	<.001	<.001	3	7
HNSC	GPSM3 →	+0.530	+0.075	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051882 vs ARHGAP25_S512 — LSCC

Explore this scatter interactively →