Mitochondrial depolarization

Across TCGA patient cohorts, RNA activity of the Mitochondrial depolarization pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MIR942, TBXAS1, and AKR1C1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial depolarization activity versus MIR942 in GBM (Pearson r = 0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MIR942 →	-0.657	-0.105	.002	.002	3	4
GBM	TBXAS1 →	+0.651	+0.090	.007	.007	3	4
GBM	AKR1C1 →	+0.723	+0.085	.004	.006	3	4
GBM	ANKRD44-AS1 →	+0.509	+0.098	<.001	.005	3	4
GBM	SNRPGP10 →	-0.696	-0.087	<.001	<.001	3	4
OV	BTK →	+1.124	+0.140	.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051882 vs MIR942 — GBM

Explore this scatter interactively →