Mitochondrial depolarization

Across TCGA patient cohorts, RNA activity of the Mitochondrial depolarization pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CNNM3_S673, SEC22B_S137, and TOR2A, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial depolarization activity versus CNNM3_S673 in GBM (Pearson r = -0.09).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CNNM3_S673 →	+0.634	+0.100	.001	<.001	3	3
OV	SEC22B_S137 →	+0.727	+0.179	<.001	<.001	3	3
OV	TOR2A →	+0.470	+0.143	<.001	<.001	3	3
LUAD	SYNPO_S854 →	-0.299	-0.138	<.001	<.001	3	3
OV	MAP2K4_S394 →	+1.864	+0.172	<.001	<.001	3	3
UCEC	HSPB8_S57 →	+1.158	+0.357	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051882 vs CNNM3_S673 — GBM

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