Mitochondrial depolarization

Across TCGA cell cohorts, RNA activity of the Mitochondrial depolarization pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRDMT1, EN1, and ZNF417, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TRDMT1 grouped by Mitochondrial depolarization-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	TRDMT1 →	+0.210	+0.485	.002	.005	3	2
BREAST	EN1 →	-0.296	-0.447	.001	.002	3	2
LUNG_SCLC	ZNF417 →	-0.596	-0.358	.003	<.001	3	2
BREAST	CCT8L2 →	+0.263	+0.447	.002	.002	3	2
BREAST	S1PR3 →	-0.286	-0.447	.006	.002	3	2
LUNG_SCLC	UHMK1 →	-0.156	-0.284	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TRDMT1 by Mitochondrial depolarization activity — BREAST

Explore this box plot interactively →