Mitochondrial depolarization

Across TCGA cell cohorts, RNA activity of the Mitochondrial depolarization pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CEP19, TUBB1, and RENBP, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial depolarization activity versus CEP19 in LUNG_SCLC (Pearson r = 0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CEP19 →	+0.798	+0.314	.002	<.001	3	2
LUNG_SCLC	TUBB1 →	-0.403	-0.399	<.001	<.001	3	1
LUNG_SCLC	RENBP →	-1.212	-0.316	.007	.002	3	1
LUNG_SCLC	C19orf44 →	-0.502	-0.363	.003	.004	3	1
LUNG_SCLC	SEC61B →	-0.641	-0.270	.004	.007	3	1
LUNG_SCLC	GPN3 →	-0.620	-0.377	.004	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051882 vs CEP19 — LUNG_SCLC

Explore this scatter interactively →