Regulation of mitochondrial membrane potential

Across TCGA patient cohorts, RNA activity of the Regulation of mitochondrial membrane potential pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SYNPO, NECAP2, and RANBP2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of mitochondrial membrane potential activity versus SYNPO in GBM (Pearson r = 0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SYNPO →	+0.344	+0.044	<.001	<.001	3	6
LSCC	NECAP2 →	+0.248	+0.042	<.001	<.001	3	6
GBM	RANBP2 →	-0.208	-0.052	<.001	<.001	3	6
GBM	LIG3 →	-0.307	-0.040	<.001	<.001	3	6
GBM	SIGLEC1 →	+0.421	+0.029	.003	.003	3	6
GBM	SEH1L →	-0.138	-0.044	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051881 vs SYNPO — GBM

Explore this scatter interactively →