Regulation of mitochondrial membrane potential

Across TCGA patient cohorts, RNA activity of the Regulation of mitochondrial membrane potential pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPS7, GSAP, and MVP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of mitochondrial membrane potential activity versus RPS7 in COAD (Pearson r = -0.03).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RPS7 →	-0.269	-0.065	.005	.003	3	5
LUAD	GSAP →	+0.445	+0.145	.001	.001	3	5
BRCA	MVP →	+0.857	+0.146	<.001	<.001	3	4
BRCA	IL6ST →	+1.058	+0.131	.008	.006	3	4
LUAD	AURKB →	-0.710	-0.136	.004	.002	3	4
LSCC	SFTPA2 →	+2.630	+0.111	.002	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051881 vs RPS7 — COAD

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