Regulation of mitochondrial membrane potential

Across TCGA cell cohorts, RNA activity of the Regulation of mitochondrial membrane potential pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDZD3, ANXA4, and SYAP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PDZD3 grouped by Regulation of mitochondrial membrane potential-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PDZD3 →	+1.549	+0.207	.002	.004	3	5
KIDNEY	ANXA4 →	+1.844	+0.284	.007	.003	3	5
BONE	SYAP1 →	+0.952	+0.190	<.001	<.001	3	4
LARGE_INTESTINE	SGK2 →	+1.798	+0.209	.008	.001	3	4
PANCREAS	CAMSAP3 →	+1.091	+0.245	.008	.005	3	4
KIDNEY	DTX4 →	+1.333	+0.339	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PDZD3 by Regulation of mitochondrial membrane potential activity — LARGE_INTESTINE

Explore this box plot interactively →