Regulation of mitochondrial membrane potential

Across TCGA cell cohorts, RNA activity of the Regulation of mitochondrial membrane potential pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TOX2, PFDN4, and ZFP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of mitochondrial membrane potential activity versus TOX2 in BLOOD_Leukemia (Pearson r = -0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TOX2 →	-2.093	-0.200	<.001	<.001	3	5
SKIN	PFDN4 →	-0.795	-0.194	.003	.004	3	5
SKIN	ZFP1 →	-0.773	-0.203	<.001	.005	3	4
BLOOD_Leukemia	CDKN2A →	+3.290	+0.168	<.001	.003	3	4
LIVER	GFPT2 →	-3.324	-0.310	<.001	.005	3	4
STOMACH	SELENBP1 →	+2.981	+0.369	.006	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051881 vs TOX2 — BLOOD_Leukemia

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