General adaptation syndrome

Across TCGA patient cohorts, RNA activity of the General adaptation syndrome pathway is significantly associated with the RNA expression of multiple genes, with the PCPG cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NR4A2, FOSB, and NR4A1, each associated with the pathway in up to 29 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, General adaptation syndrome activity versus NR4A2 in PCPG (Pearson r = 0.02).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PCPG	NR4A2 →	+1.554	+0.060	<.001	<.001	3	29
MESO	FOSB →	+3.542	+0.089	<.001	<.001	3	22
CHOL	NR4A1 →	+2.103	+0.099	<.001	.003	2	23
MESO	NR4A1AS →	+1.840	+0.108	<.001	<.001	3	22
DLBC	TMEM74 →	-0.507	-0.090	<.001	<.001	2	22
MESO	ZFP36 →	+2.183	+0.082	<.001	<.001	3	20

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051866 vs NR4A2 — PCPG

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