General adaptation syndrome

Across TCGA patient cohorts, RNA activity of the General adaptation syndrome pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BHLHE40_S192, MPLKIP_S133, and SUPT6H_S91, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, General adaptation syndrome activity versus BHLHE40_S192 in BRCA (Pearson r = 0.01).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	BHLHE40_S192 →	+0.644	+0.076	<.001	<.001	3	6
GBM	MPLKIP_S133 →	+0.471	+0.141	<.001	<.001	3	6
GBM	SUPT6H_S91 →	+0.531	+0.218	.001	.002	3	5
LSCC	PIK3C2A_S259 →	+0.491	+0.128	<.001	<.001	3	5
LUAD	PPP1R12C_S509 →	+0.532	+0.113	<.001	.005	3	5
GBM	ARRDC1 →	+0.283	+0.110	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051866 vs BHLHE40_S192 — BRCA

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