General adaptation syndrome

Across TCGA patient cohorts, RNA activity of the General adaptation syndrome pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPP1R16B, KATNAL1, and CPEB3, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, General adaptation syndrome activity versus PPP1R16B in GBM (Pearson r = 0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PPP1R16B →	+1.192	+0.811	<.001	.005	3	2
GBM	KATNAL1 →	+0.463	+0.793	<.001	.002	3	2
GBM	CPEB3 →	+0.605	+0.909	.002	.001	3	2
GBM	CDKN1B →	+0.329	+0.752	<.001	.001	3	2
GBM	ARFGEF3 →	+0.769	+0.896	.001	<.001	3	2
GBM	STRN →	+0.315	+0.953	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051866 vs PPP1R16B — GBM

Explore this scatter interactively →