Protein autoubiquitination

Across TCGA patient cohorts, RNA activity of the Protein autoubiquitination pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLK4, CIP2A, and KPNA2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein autoubiquitination activity versus PLK4 in UCEC (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PLK4 →	+0.662	+0.657	<.001	<.001	3	4
UCEC	CIP2A →	+0.735	+0.738	.002	<.001	3	4
UCEC	KPNA2 →	+0.754	+0.741	<.001	<.001	3	4
UCEC	BIRC5 →	+0.888	+0.691	.009	<.001	3	4
UCEC	CDC7 →	+0.654	+0.612	.001	.001	3	4
COAD	ELAC1 →	+0.292	+0.346	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051865 vs PLK4 — UCEC

Explore this scatter interactively →