Protein autoubiquitination

Across TCGA cell cohorts, RNA activity of the Protein autoubiquitination pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPP4C, PPM1D, and UBE2D3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PPP4C grouped by Protein autoubiquitination-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PPP4C →	-0.279	-0.210	<.001	<.001	3	5
SOFT_TISSUE	PPM1D →	-0.163	-0.173	.002	.008	3	4
OVARY	UBE2D3 →	-0.303	-0.247	.003	.002	3	4
STOMACH	BRD1 →	-0.189	-0.227	<.001	<.001	3	4
STOMACH	IPO7 →	-0.526	-0.184	.004	.002	3	4
OESOPHAGUS	PABPC3 →	-0.282	-0.192	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PPP4C by Protein autoubiquitination activity — SKIN

Explore this box plot interactively →