Protein autoubiquitination

Across TCGA cell cohorts, RNA activity of the Protein autoubiquitination pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ELF4, MIDN, and ACSL5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ELF4 grouped by Protein autoubiquitination-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	ELF4 →	-1.041	-0.781	.003	.003	3	4
KIDNEY	MIDN →	-0.890	-1.103	.004	<.001	3	4
LUNG_NSCLC_LUSC	ACSL5 →	-3.575	-0.931	<.001	.004	3	3
BONE	PPP2R5E →	-1.147	-0.215	<.001	.002	3	3
LARGE_INTESTINE	SLC18B1 →	+1.150	+1.015	.007	.001	3	3
LARGE_INTESTINE	VOPP1 →	-0.954	-1.081	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ELF4 by Protein autoubiquitination activity — CNS

Explore this box plot interactively →