Protein autoubiquitination

Across TCGA cell cohorts, RNA activity of the Protein autoubiquitination pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAL2, ACP3, and VAMP8, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein autoubiquitination activity versus MAL2 in LIVER (Pearson r = -0.75).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	MAL2 →	-4.581	-0.576	<.001	<.001	3	7
BLOOD_Leukemia	ACP3 →	-1.147	-0.892	.005	<.001	3	7
BLOOD_Leukemia	VAMP8 →	-2.584	-0.735	<.001	.002	3	6
LUNG_NSCLC_LUAD	HOOK1 →	-1.445	-0.622	.002	.008	3	6
STOMACH	MEST →	-3.324	-1.486	.006	.009	3	5
LIVER	SHANK2 →	-2.388	-0.661	.003	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051865 vs MAL2 — LIVER

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