Modulation by host of symbiont process

Across TCGA patient cohorts, RNA activity of the Modulation by host of symbiont process pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAD54L, HMGA2, and CDCA5, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Modulation by host of symbiont process activity versus RAD54L in LUAD (Pearson r = 0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RAD54L →	+0.562	+0.181	.001	<.001	3	7
GBM	HMGA2 →	+0.927	+0.177	.002	.002	2	7
LUAD	CDCA5 →	+0.589	+0.144	.001	<.001	3	6
LUAD	AUNIP →	+0.707	+0.187	<.001	.001	3	6
PDAC	PLSCR4 →	-0.299	-0.132	.004	.005	3	6
UCEC	EXO1 →	+0.757	+0.164	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051851 vs RAD54L — LUAD

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