Modulation by host of symbiont process

Across TCGA cell cohorts, RNA activity of the Modulation by host of symbiont process pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TENM3, NTAQ1, and GXYLT2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TENM3 grouped by Modulation by host of symbiont process-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	TENM3 →	-1.446	-0.208	.009	.008	3	4
LIVER	NTAQ1 →	+1.114	+0.320	.003	.007	3	4
LUNG_NSCLC_LUAD	GXYLT2 →	-1.317	-0.136	<.001	.009	3	3
PANCREAS	TAF7 →	-0.679	-0.189	.005	.003	3	3
BLOOD_Leukemia	TP53 →	-1.577	-0.117	.004	.007	2	4
CNS	NRP2 →	-1.750	-0.194	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TENM3 by Modulation by host of symbiont process activity — CNS

Explore this box plot interactively →