Modulation by host of symbiont process

Across TCGA cell cohorts, RNA activity of the Modulation by host of symbiont process pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are F3, PC, and PSKH1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Modulation by host of symbiont process activity versus F3 in KIDNEY (Pearson r = -0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	F3 →	-4.100	-0.282	.003	.004	3	5
LUNG_SCLC	PC →	+1.113	+0.201	<.001	<.001	3	5
STOMACH	PSKH1 →	+0.725	+0.199	.003	<.001	3	5
SKIN	GXYLT1 →	+1.001	+0.159	.001	.004	3	5
UPPER_AERODIGESTIVE_TRACT	PPP1CA →	+0.779	+0.161	.005	.002	3	4
BLOOD_Lymphoma	NDUFA5 →	+0.566	+0.114	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051851 vs F3 — KIDNEY

Explore this scatter interactively →