Regulation of synapse structural plasticity

Across TCGA patient cohorts, RNA activity of the Regulation of synapse structural plasticity pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EDEM3, DENND4C_S1000, and GCC2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of synapse structural plasticity activity versus EDEM3 in OV (Pearson r = -0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	EDEM3 →	-0.266	-0.065	<.001	.001	3	4
COAD	DENND4C_S1000 →	+0.616	+0.072	.006	.001	3	4
COAD	GCC2 →	-0.259	-0.053	<.001	<.001	3	4
HNSC	SOWAHB_S271 →	-0.501	-0.462	<.001	.005	3	3
BRCA	TOLLIP →	+0.273	+0.054	.007	.005	3	3
HNSC	IRF2BPL_S336 →	-0.875	-0.178	.004	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051823 vs EDEM3 — OV

Explore this scatter interactively →