Regulation of synapse structural plasticity

Across TCGA patient cohorts, RNA activity of the Regulation of synapse structural plasticity pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FHL5, TEK, and EMCN, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of synapse structural plasticity activity versus FHL5 in CCRCC (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	FHL5 →	+0.904	+0.652	<.001	<.001	3	8
CCRCC	TEK →	+1.230	+0.694	<.001	<.001	3	8
CCRCC	EMCN →	+1.424	+0.766	<.001	<.001	3	8
CCRCC	S1PR1 →	+1.003	+0.710	<.001	<.001	3	8
HNSC	SELP →	+0.952	+0.425	<.001	<.001	3	8
CCRCC	MYCT1 →	+1.048	+0.814	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051823 vs FHL5 — CCRCC

Explore this scatter interactively →