Regulation of synapse structural plasticity

Across TCGA cell cohorts, RNA activity of the Regulation of synapse structural plasticity pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DYNC1H1, SYDE1, and RIPK3, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of synapse structural plasticity activity versus DYNC1H1 in LUNG_NSCLC_LUAD (Pearson r = -0.94).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	DYNC1H1 →	-1.029	-2.131	.002	.004	3	3
LUNG_NSCLC_LUAD	SYDE1 →	-2.545	-2.131	<.001	.004	3	2
LUNG_NSCLC_LUAD	RIPK3 →	+2.239	+1.940	<.001	<.001	3	2
LUNG_NSCLC_LUAD	LRP3 →	-1.076	-1.940	.006	<.001	3	2
LUNG_NSCLC_LUAD	SPOCD1 →	-2.530	-2.131	<.001	.004	3	2
LUNG_NSCLC_LUAD	LRRC49 →	-1.383	-1.940	.008	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051823 vs DYNC1H1 — LUNG_NSCLC_LUAD

Explore this scatter interactively →