Positive regulation of hair follicle development

Across TCGA patient cohorts, RNA activity of the Positive regulation of hair follicle development pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are KRT17, MMP14, and ACIN1_S729, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of hair follicle development activity versus KRT17 in LUAD (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	KRT17 →	+1.469	+0.081	<.001	<.001	3	6
BRCA	MMP14 →	+0.476	+0.054	<.001	<.001	3	6
BRCA	ACIN1_S729 →	-0.531	-0.050	<.001	<.001	3	6
LUAD	AHNAK_T4100 →	+0.570	+0.055	<.001	.006	3	6
BRCA	TOM1 →	+0.304	+0.064	<.001	<.001	3	6
BRCA	COL11A1 →	+0.741	+0.047	.007	.005	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051798 vs KRT17 — LUAD

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