Positive regulation of hair follicle development

Across TCGA patient cohorts, RNA activity of the Positive regulation of hair follicle development pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KRT17, RAET1L, and PERP, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of hair follicle development activity versus KRT17 in LUAD (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	KRT17 →	+2.026	+0.309	<.001	.001	3	6
BRCA	RAET1L →	+0.958	+0.824	<.001	<.001	3	5
LSCC	PERP →	+1.036	+0.231	<.001	.002	3	5
LSCC	DIAPH2 →	+0.856	+0.272	<.001	<.001	3	5
LSCC	PUS7 →	+0.832	+0.226	<.001	<.001	3	5
LSCC	SNRNP48 →	+0.694	+0.305	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051798 vs KRT17 — LUAD

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