Positive regulation of hair follicle development

Across TCGA cell cohorts, RNA activity of the Positive regulation of hair follicle development pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGAP11A, MAF1, and USP40, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ARHGAP11A grouped by Positive regulation of hair follicle development-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	ARHGAP11A →	+0.834	+1.021	.001	<.001	3	4
LUNG_NSCLC_LUSC	MAF1 →	+0.850	+1.368	.006	.005	3	4
OVARY	USP40 →	-0.714	-0.644	<.001	.003	3	4
KIDNEY	RNF121 →	+0.991	+1.340	.005	<.001	3	3
LARGE_INTESTINE	SYAP1 →	+0.632	+0.939	.004	.006	3	3
KIDNEY	TSPAN17 →	+0.641	+1.032	.009	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ARHGAP11A by Positive regulation of hair follicle development activity — CNS

Explore this box plot interactively →