Regulation of hair follicle development

Across TCGA cell cohorts, RNA activity of the Regulation of hair follicle development pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PAXBP1, NRXN3, and CH25H, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PAXBP1 grouped by Regulation of hair follicle development-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	PAXBP1 →	+0.346	+0.516	.009	<.001	3	4
PANCREAS	NRXN3 →	+0.301	+0.380	<.001	<.001	3	4
LUNG_NSCLC_LUAD	CH25H →	+0.214	+0.405	.002	.001	3	4
PANCREAS	LAMC2 →	+0.422	+0.279	.004	.004	3	3
STOMACH	FLNC →	+0.280	+0.584	.006	<.001	3	3
STOMACH	SOX13 →	-0.166	-0.522	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PAXBP1 by Regulation of hair follicle development activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →