Regulation of hair follicle development

Across TCGA cell cohorts, RNA activity of the Regulation of hair follicle development pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LSR, OVOL1, and S100A14, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of hair follicle development activity versus LSR in LUNG_SCLC (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	LSR →	+2.724	+0.324	.004	.006	3	6
STOMACH	OVOL1 →	+2.368	+0.503	.001	<.001	3	6
STOMACH	S100A14 →	+6.792	+0.496	<.001	<.001	3	6
STOMACH	FXYD3 →	+6.231	+0.424	<.001	.001	3	5
STOMACH	BIK →	+2.104	+0.382	<.001	<.001	3	5
OESOPHAGUS	LY6D →	+4.166	+0.417	.002	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051797 vs LSR — LUNG_SCLC

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