Medium-chain fatty acid catabolic process

Across TCGA patient cohorts, RNA activity of the Medium-chain fatty acid catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DOP1B, AGPS, and ABHD3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Medium-chain fatty acid catabolic process activity versus DOP1B in OV (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	DOP1B →	+0.304	+0.057	<.001	.004	3	6
LUAD	AGPS →	+0.218	+0.073	.001	.001	3	5
OV	ABHD3 →	+0.802	+0.139	.001	.004	3	5
LUAD	ACBD5 →	+0.334	+0.080	.001	<.001	3	5
PDAC	SGSM3 →	+0.473	+0.078	<.001	<.001	3	5
LSCC	CAMSAP2 →	-0.314	-0.084	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051793 vs DOP1B — OV

Explore this scatter interactively →