Medium-chain fatty acid metabolic process

Across TCGA patient cohorts, RNA activity of the Medium-chain fatty acid metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CES1, CRAT, and AKR1B10, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Medium-chain fatty acid metabolic process activity versus CES1 in LSCC (Pearson r = 0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CES1 →	+1.351	+0.067	<.001	<.001	3	8
BRCA	CRAT →	+0.765	+0.073	<.001	<.001	3	7
LSCC	AKR1B10 →	+1.973	+0.072	<.001	<.001	3	5
OV	AKR1C2 →	+1.517	+0.071	<.001	<.001	3	5
LSCC	AKR1C3 →	+1.342	+0.053	<.001	.003	3	5
LSCC	GSTM3 →	+0.930	+0.053	.005	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051791 vs CES1 — LSCC

Explore this scatter interactively →