Medium-chain fatty acid metabolic process

Across TCGA patient cohorts, RNA activity of the Medium-chain fatty acid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CROT, PDE6B, and SLC11A2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Medium-chain fatty acid metabolic process activity versus CROT in BRCA (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CROT →	+0.977	+0.181	.001	.004	3	4
BRCA	PDE6B →	-0.705	-0.181	.009	.008	3	4
UCEC	SLC11A2 →	+0.675	+0.235	<.001	<.001	3	4
UCEC	NCDN →	+0.509	+0.148	<.001	.007	3	4
BRCA	CDHR3 →	-1.028	-0.201	.001	.003	3	3
GBM	PMP2 →	-0.994	-0.178	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051791 vs CROT — BRCA

Explore this scatter interactively →