Medium-chain fatty acid metabolic process

Across TCGA cell cohorts, RNA activity of the Medium-chain fatty acid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LMNTD2, S100A2, and MTX2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LMNTD2 grouped by Medium-chain fatty acid metabolic process-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	LMNTD2 →	-0.758	-1.140	.001	<.001	3	5
SOFT_TISSUE	S100A2 →	+3.546	+1.644	<.001	<.001	3	4
PANCREAS	MTX2 →	+0.434	+0.951	<.001	.001	3	4
BREAST	USP30 →	+0.830	+1.388	<.001	<.001	3	4
STOMACH	BCL2L15 →	-2.142	-1.130	.006	.003	3	4
LIVER	BAHD1 →	-0.689	-1.591	.006	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LMNTD2 by Medium-chain fatty acid metabolic process activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →