Medium-chain fatty acid metabolic process

Across TCGA cell cohorts, RNA activity of the Medium-chain fatty acid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IFT122, FBXO42, and ACOT7, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Medium-chain fatty acid metabolic process activity versus IFT122 in LUNG_SCLC (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	IFT122 →	+0.675	+0.176	.001	.003	3	6
BONE	FBXO42 →	+0.831	+0.221	<.001	.003	3	5
PANCREAS	ACOT7 →	+1.281	+0.283	.002	.003	2	6
LUNG_NSCLC_LUSC	ZFX →	+0.869	+0.349	.009	.004	3	5
KIDNEY	PRX →	+0.641	+0.257	.004	.003	3	5
LIVER	VAMP1 →	+0.805	+0.286	.006	<.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051791 vs IFT122 — LUNG_SCLC

Explore this scatter interactively →